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当前位置: 首页 > 产品中心 > > Oxford/Anti-human Peptidylarginine Deaminase-4 (PAD4), murine monoclonal/Kit/NF15
商品详细Oxford/Anti-human Peptidylarginine Deaminase-4 (PAD4), murine monoclonal/Kit/NF15
Oxford/Anti-human Peptidylarginine Deaminase-4 (PAD4), murine monoclonal/Kit/NF15
Oxford/Anti-human Peptidylarginine Deaminase-4 (PAD4), murine monoclonal/Kit/NF15
商品编号: NF15
品牌: oxfordbiomed
市场价: ¥8500.00
美元价: 4250.00
产地: 美国(厂家直采)
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产品分类: 其他
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商品介绍

Peptidylarginine Deiminases (PADs) catalyze the post-translational conversion of arginine residues to citrulline. PAD4 is localized to the nucleus of neutrophils where it citrullinates the core histones H3, H4 and H2A. PAD4-mediated histone citrullination is required for the generation of Neutrophil Extracellular Traps (NETs), aggregates of DNA and anti-microbial proteins that are expelled from neutrophils to ensnare and kill bacteria.  The majority of patients with Rheumatoid Arthritis (RA) produce antibodies to citrullinated proteins, suggesting a role for PAD4 in the pathogenesis of this disease.

PAD4 has also been recognized as a transcriptional coregulator. It is recruited to the promoters of genes regulated by the estrogen receptor (ER) and p53, where it catalyzes the citrullination of the N-terminal portion of histone H3 and inhibits arginine methylation. Recently, it was reported that a member of the ETS oncogene family, Elk-1 is citrullinated by PAD4 to activate c-fos expression in breast cancer cells.

References:

Jones JE, Causey CP, Knuckley B, Slack-Noyes JL, Thompson PR. Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential. Curr Opin Drug Discov Devel. 2009 Sep;12(5):616-27. PMID: 19736621; PMCID: PMC3771078.

Rohrbach AS, Slade DJ, Thompson PR, Mowen KA. Activation of PAD4 in NET formation. Front Immunol. 2012;3:360. Published 2012 Nov 29. doi:10.3389/fimmu.2012.00360

Urano T, Nakayama M, Ohara O, Yamamura K, Yamamoto K, Miyazaki T. PAD4 regulates proliferation of multipotent haematopoietic cells by controlling c-myc expression. Nat Commun. 2013;4:1836. doi: 10.1038/ncomms2862. PMID: 23673621; PMCID: PMC3674250.

Koushik S, Joshi N, Nagaraju S, Mahmood S, Mudeenahally K, Padmavathy R, Jegatheesan SK, Mullangi R, Rajagopal S. PAD4: pathophysiology, current therapeutics and future perspective in rheumatoid arthritis. Expert Opin Ther Targets. 2017 Apr;21(4):433-447. doi: 10.1080/14728222.2017.1294160. Epub 2017 Feb 22. PMID: 28281906.

Nakashima K, Arai S, Suzuki A, Nariai Y, Urano T, Nakayama M, Ohara O, Yamamura K, Yamamoto K, Miyazaki T. PAD4 regulates proliferation of multipotent haematopoietic cells by controlling c-myc expression. Nat Commun. 2013;4:1836. doi: 10.1038/ncomms2862. PMID: 23673621; PMCID: PMC3674250.

品牌介绍
Oxford Biomedical Research(OBR)公司由Denis M. Callewaert博士于1984年建立。OBR公司开发,生产和销售检测试剂盒,重组蛋白和应用于生物医学和制药研究的抗体,现已具有400多种产品。我们产品的重点是对引发多种疾病的两大风险因素氧化应激和慢性炎症的生物标志物的识别与检测。我们采用专有技术,开发组织和疾病的特异性生物标志物。